The challenge of drug induced liver injury dili challenges and management of liver cirrhosis preface gerbes al jaeschke h pmid 26159258 pubmed indexed for medline publication types introductory journal article mesh terms chemical and drug induced liver injury humans liver cirrhosis. Drug induced liver injury dili has a considerable impact on human health and is a major challenge in drug safety assessments dili is a frequent cause of liver injury and a leading reason for . The diagnosis of drug induced liver injury dili is challenging and based on complex diagnostic criteria dili falls into two main categories i intrinsic dose dependent type a reactions ii idiosyncratic or type b reactions which are usually not predictable idiosyncratic reactions can be im genetic and molecular factors in drug induced liver injury a review curr drug saf 2007 . Although drug induced liver injury dili is a rare clinical event it carries significant morbidity and mortality leaving it as the leading cause of acute liver failure in the united states it is one of the most challenging diagnoses encountered by gastroenterologists the development of various drug injury networks has played a vital role in expanding our knowledge regarding drug . Drug induced liver injury dili remains one of the most challenging disorders faced by gastroenterologists the wide range of presentations and culprit agents and lack of objective diagnostic tests make its diagnosis and management particularly difficult despite its low incidence in the general population gastroenterologists must always consider the possibility of dili in patients with
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